Aloe vera
Aloe vera as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury
Aloe vera and DILI
While Aloe vera is generally considered safe when used topically, there have been reported cases of liver injury associated with the ingestion of Aloe vera supplements or extracts. The exact mechanism of how Aloe vera may cause liver injury is not fully understood, but it is believed to be related to the presence of anthraquinones, which are compounds with potential toxic effects on the liver.
It is important to be cautious when using Aloe vera products internally, especially in high doses or for an extended period of time. If you experience any symptoms of liver injury, such as jaundice, abdominal pain, or dark urine, after consuming Aloe vera supplements, it is important to seek medical attention immediately.
As with any herbal supplement, it is recommended to consult with a healthcare provider before using Aloe vera internally, especially if you have a history of liver disease or are taking medications that may interact with Aloe vera.
Supplements for DILI
Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.
-
Green tea extract
Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.
-
Greater celandine
Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.
-
Chaparral
Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.
-
Germander
Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.
-
Mistletoe
Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.
-
Skullcap
Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.
-
Valerian
Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.
-
Kava kava
Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.
-
St. John's wort
Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.
-
Ginseng
Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.
-
Aloe vera
Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.
-
Ashwagandha
Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.
-
Andrographis
Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.
-
Noni juice
Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.
-
Peppermint oil
Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.
-
Kratom
Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.
-
Ephedra
Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.
Disclaimer